Accumulating evidence has demonstrated that autism is often characterized by complex abnormalities such as oxidative stress, mitochondrial dysfunction, inflammation, certain genetic abnormalities, exposure(s) to environmental toxicants, immunological abnormalities, infections, and in some cases, developmental regression and seizures. These abnormalities may contribute to the symptoms of autism, such as sleep problems, obsessive behavior, speech delay, impaired social interaction, self-stimulatory behavior, hyperactivity, inattention, and abnormal gastrointestinal findings.  Many children with autism have a unique combination of these abnormalities and may possess some or all of these problems simultaneously. The early identification of these abnormalities helps clinicians and parents to choose the most effective treatment options.  Dr. Rossignol’s aim is to identify the unique biochemical abnormalities that each individual possesses (e.g., the biochemical fingerprint) and works to create the most effective treatments for these abnormalities using evidence-based medicine principles.

NEW: A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures

Download the review here: http://www.nature.com/mp/journal/vaop/ncurrent/pdf/mp2011165a.pdf

NEW: Melatonin in autism spectrum disorders: a systematic review and meta-analysis
Download the study here: http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8749.2011.03980.x/abstract
View related Reuters Article: http://www.reuters.com/article/2011/04/26/idUS168076+26-Apr-2011+PRN20110426

NEW: Mitochondrial Dysfunction Linked to Autism
Download the study here (requires a free Medscape account): http://www.medscape.com/viewarticle/736560
Click here for related article: http://pn.psychiatryonline.org/content/46/6/18.1.full

The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism:
an open-label pilot study.  
Download the study here: http://www.biomedcentral.com/content/pdf/1471-2431-7-36.pdf   

Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial, a 62-patient trial
Download the study here: http://www.biomedcentral.com/content/pdf/1471-2431-9-21.pdf  

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
Download the study here: http://www.nature.com/mp/journal/vaop/ncurrent/pdf/mp2010136a.pdf

Diagnosis Autism: Now What? A Simplified Biomedical Approach

NEW: Folate Autism Receptor Autoimmunity in Autism Spectrum Disorders
Presented at the Autism One May 2011 conference

Caring for medically complex children and adults is, obviously, complex.  There are no “cookie cutter” templates that can be followed that will work consistently for all individuals.  Each individual possesses a unique medical puzzle that is waiting to be solved.  That is why Dr. Rossignol treats each person individually, providing care with one goal in mind – to unlock this puzzle and allow each individual to thrive.

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